Skin diseases A-Z Skin diseases S – Z Syphilis (Lues) January 31, 2025 / August 12, 2026 by Dick van Gerwen | Leave a Comment Symptoms Syphilis progresses through different stages, each with its own symptoms: Primary syphilis: The first sign is often a single, painless sore at the infection site, usually on the genitals, rectum, or mouth. Secondary syphilis: Weeks to months after the initial infection, a rash may occur, often on the palms of the hands and soles […] Read more » Congenital syphilis Lues Penicillin treatment Rash on hands and feet Sexual health Sexually transmitted infections STI Syphilis Treponema pallidum